Bayesian methods and ethics in a clinical trial design / / edited by Joseph B. Kadane

• Record Nr.: UNINA9910139566603321
• Pubbl/distr/stampa: New York : , : John Wiley & Sons, Inc., , 1996; ©1996
• ISBN: 1-283-28129-5; 9786613281296; 1-118-15060-0; 1-118-15059-7
• Descrizione fisica: 1 online resource (344 p.)
• Collana: Wiley Series in Probability and Statistics
• Disciplina: 519.542
• Soggetti: Clinical trials - Moral and ethical aspects; Electronic books.
• Lingua di pubblicazione: Inglese
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Note generali: Description based upon print version of record.
• Nota di bibliografia: Includes bibliographical references at the end of each chapters and indexes.
• Nota di contenuto: Bayesian Methods and Ethics in a Clinical Trial Design; Contents; Preface; About the Authors; PART I MAJOR ISSUES; 1 Introduction; 2 Ethically Optimizing Clinical Trials; 3 Admissibility of Treatments; 4 Statistical Issues in the Analysis of Data Gathered in the New Designs; PART II TEST CASE: VERAPAMIL/NITROPRUSSIDE; 5 Introduction to the Verapamil/Nitroprusside Study; 6 The Mechanics of Conducting a Clinical Trial; 7 The Verapamil/Nitroprusside Study: Comments on ""The Mechanics of Conducting a Clinical Trial""; 8 Computational Aspects of the Verapamil/Nitroprusside Study; 9 Being an Expert; 10 Issues of Statistical Design11 Operational History and Procedural Feasibility; 12 Verapamil versus Nitroprusside: Results of the Clinical Trial I; 13 Verapamil versus Nitroprusside: Results of the Clinical Trial II; PART III OTHER ISSUES; 14 The Law of Clinical Testing with Human Subjects: Legal Implications of the New and Existing Methodologies; 15 Commentary I on ""The Law of Clinical Testing with Human Subjects""; 16 Commentary II on ""The Law of Clinical Testing with Human Subjects""; 17 Author's Response to Commentaries I and II; 18 Whether to Participate in a Clinical Trial: The Patient's ViewPART IV EPILOGUE; 19 Epilogue; NAME INDEX; SUBJECT INDEX
• Sommario/riassunto: How to conduct clinical trials in an ethical and scientifically responsible mannerThis book presents a methodology for clinical trials that produces improved health outcomes for patients while obtaining sound and unambiguous scientific data. It centers around a real-world test case--involving a treatment for hypertension after open heart surgery--and explains how to use Bayesian methods to accommodate both ethical and scientific imperatives.The book grew out of the direct involvement in the project by a diverse group of experts in medicine, statistics, philosophy, and the law.