Sherlock's diseases of the liver and biliary system / / edited by James S. Dooley ... [et al.]

• Record Nr.: UNINA9910139551703321
• Pubbl/distr/stampa: Chichester, West Sussex ; ; Hoboken, NJ, : Wiley-Blackwell, 2011
• ISBN: 1-283-40744-2; 9786613407443; 1-4443-4129-4; 1-4443-4126-X
• Edizione: [12th ed.]
• Descrizione fisica: 1 online resource (789 p.)
• Altri autori (Persone): DooleyJames (James S.); SherlockSheila, Dame
• Disciplina: 616.3/6; 616.36
• Soggetti: Liver - Diseases; Biliary tract - Diseases
• Lingua di pubblicazione: Inglese
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Note generali: Description based upon print version of record.
• Nota di bibliografia: Includes bibliographical references and index.
• Nota di contenuto: Sherlock's Diseases of the Liver and Biliary System; Contents; List of Contributors; Preface to the Twelfth Edition; Preface to the First Edition; CHAPTER 1: Anatomy and Function; Development of the liver and bile ducts; Anatomy of the liver; Functional liver anatomy: sectors and segments; Anatomical abnormalities of the liver; Anatomy of the biliary tract; Surface marking; Methods of examination; Microanatomy of the liver; Hepatic ultrastructure (electron microscopy) and organelle functions; Functional heterogeneity of the liver; Dynamics of the hepatic microenvironment in physiology and diseaseHepatocyte death and regeneration; References; CHAPTER 2: Assessment of Liver Function; Selection of biochemical tests; Bile pigments; Serum enzyme tests; Quantitative assessment of hepatic function; Lipid and lipoprotein metabolism; Bile acids; Amino acid metabolism; Plasma proteins; Carbohydrate metabolism; Effects of ageing on the liver; References; CHAPTER 3: Biopsy of the Liver; Selection and preparation of the patient; Techniques; Risks and complications; Sampling variability; Naked-eye appearances; Preparation of the specimenInterpretation; Indications; Special methods; References; CHAPTER 4: Haematological Disorders of the Liver; The liver and blood coagulation; Haemolytic jaundice; The liver in haemolytic anaemias; The liver in myelo- and lymphoproliferative disease; Leukaemia; Bone marrow transplantation; Lymphoma; Lipid storage diseases; References; CHAPTER 5: Acute Liver Failure; Definition; Epidemiology and aetiologies; Clinical features; Initial investigations; Complications and management of acute liver failure; Specific therapies; Prognosis; Liver transplantation; Liver support systemsConclusion; References; CHAPTER 6: Hepatic Fibrogenesis; Introduction; Natural history of hepatic fibrosis; Cellular and molecular features of hepatic fibrosis; Clinical aspects of hepatic fibrosis; Emerging antifibrotic targets and strategies; References; CHAPTER 7: Hepatic Cirrhosis; Definition; Causes of cirrhosis; Anatomical diagnosis; Reversible cirrhosis; Clinical cirrhosis: compensated versus decompensated; Vasodilatation and hyperdynamic circulation; Prognosis (Child-Pugh score, MELD, UKELD); Clinical and pathological associations; Management; References; CHAPTER 8: Hepatic Encephalopathy in Patients with CirrhosisClassification; Diagnosis; Differential diagnosis; Hepatic encephalopathy and liver transplantation; Prognosis; Pathogenesis; Management of hepatic encephalopathy; Prevention; References; CHAPTER 9: The Hepatic Artery, Portal Venous System and Portal Hypertension: the Hepatic Veins and Liver in Circulatory Failure; The hepatic artery; The portal venous system; Haemodynamics of portal hypertension; Clinical features of portal hypertension; Diagnosis of varices; Imaging the portal venous system; Classification of portal hypertension; Extrahepatic portal venous obstruction
• Sommario/riassunto: Awarded first prize in the Internal Medicine category of the British Medical Association Book of the Year Awards, 2012 Following a Tradition of Excellence from reviews of previous editions: ""the best source of synthesized clinical wisdom""-Gastroenterology ""a tour de force in terms of knowledge and effort""-The New England Journal of Medicine ""the foremost liver book in the world""-The Journal of the American Medical Association ""beautifully produced""-Hep