Lymphocytes in MS and EAE: More than just a CD4+ World

• Record Nr.: UNINA9910261139303321
• Autore: Manu Rangachari
• Pubbl/distr/stampa: Frontiers Media SA, 2017
• Descrizione fisica: 1 online resource (160 p.)
• Collana: Frontiers Research Topics
• Soggetti: Medicine and Nursing
• Lingua di pubblicazione: Inglese
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Sommario/riassunto: Multiple sclerosis is degenerative disease of the central nervous system (CNS) in which myelin destruction and axon loss leads to the accumulation of physical, cognitive, and mental deficits. MS affects more than a million people worldwide and managing this chronic disease presents a significant health challenge. Multiple lines of evidence indicate that MS is an autoimmune disorder in which immune cells launch an inflammatory attack targeting myelin antigens. Indeed, myelin-reactive T cells and antibodies have been identified in MS patients and in animal models (namely experimental autoimmune encephalomyelitis, or EAE) that recapitulate many features of human disease. Animal model studies have demonstrated that T cells are both necessary and sufficient to initiate and sustain CNS autoimmunity. However, most MS animal models rely on the role played by CD4+ T cells and partially replicate the multiple aspects of MS pathogenesis. Thus, research in the past has focused heavily on the contribution of CD4+ T cells to the disease process; searching PubMed for "MS AND CD4" yields twice the results as corresponding searches for "CD8" or "B cell" and four times that for "NK cells". While CD4+ T cells may represent the minimum requirement to mediate CNS autoimmunity, it is clear that the immune response underlying human MS is far more complex and involves numerous other immune cells and subsets. This is well illustrated by the observation that MS patients treated with an anti-CD4 depleting antibody did not gain any clinical benefits whereas ; removal of several lymphocyte subsets using an anti-CD52 depleting antibody has been shown to impede disease progression. In particular, the pathogenic role(s) of non-CD4+ T cell lymphocytes is relatively poorly understood and under-researched, despite evidence that these subsets contribute to disease pathology or regulation. For example, the observed oligoclonal expansion of CD8+ T cells within the CNS compartment supports a local activation. CD8+ T cells with polarized cytolytic granules are seen in close proximity to oligodendrocytes and demyelinated axons in MS tissues. The presence of B cells in inflammatory lesions and antibodies in the CSF have long been recognized as features of MS and Rituximab, a B cell depleting therapy, has been shown to be highly effective to treat MS. Intriguingly, the putative MS therapeutic reagent Daclizumab may function in part through the expansion of a subset of immunoregulatory NK cells. NKT and ?d T cells may also play a role in CNS autoimmunity, given that they respond to lipid antigens and that myelin is lipid-rich. While different animal models recapitulate some of these aspects of human disease, identifying appropriate models and measures to investigate the role of these less well-understood lymphocytes in MS remains a challenge for the field. This Frontiers research topic aims to create a platform for both animal- and human-focused researchers to share their original data, hypotheses, future perspectives and commentaries regarding the role of these less-well understood lymphocyte subsets (CD8+ T cells, B cells, NK cells, NK T cells, ?d T cells) in the pathogenesis of CNS autoimmunity.

Cyberidentities : Canadian and European Presence in Cyberspace / / edited by Leen d'Haenens ; A.L. Cobb ... [et al.]

• Record Nr.: UNINA9910138895403321
• Autore: Leen D’Haenens
• Pubbl/distr/stampa: Les Presses de l’Université d’Ottawa | University of Ottawa Press, 1999; Ottawa : , : University of Ottawa Press, , 1999; ©1999
• ISBN: 9780776627106; 0776627104; 9780776615738; 0776615734
• Edizione: [1st ed.]
• Descrizione fisica: 1 online resource (224 pages) : illustrations
• Collana: International Canadian studies series = Collection internationale d'etudes canadiennes, , ISSN 1489-713X
• Disciplina: 303.48
• Soggetti: Internet - Pays de la Communaute europeenne; Autoroutes electroniques - Pays de la Communaute europeenne; Technologie de l'information - Pays de la Communaute europeenne; Internet - Canada; Autoroutes electroniques - Canada; Technologie de l'information - Canada; Internet - European Union countries; Information superhighway - European Union countries; Information technology - European Union countries; Information superhighway - Canada; Information technology - Canada
• Lingua di pubblicazione: Inglese
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Note generali: Co-published by International Council for Canadian Studies and Institute of Canadian Studies, University of Ottawa.
• Nota di bibliografia: Includes bibliographical references.; Includes bibliographical references throughout the text.
• Nota di contenuto: Preface -- Beyond Infrastructure: Canadian and European Identities in Cyberspace -- Part One: Stationary Travelers? -- The Trans-Canada Highway vs The Information Highway: The Road Less Traveled? -- On the (Information) Highway: So Is This a Journey or What? -- Part Two: ; Cyberlaw -- Human Rights in Cyberspace -- Internet and Public Order -- The Legal Aspects of Digital Signatures -- Part Three: Communities in Cyberspace -- How Comfortably Does the Internet Sit on Canada's Tundra? Reflections on Public Access to the Information Highway in the North --; Policy-Making and the Value of Electronic Forms of Public Debate: Underpinning, Assumptions and First Experiences -- Two Canadian Models of Communities on the Net: SchoolNet and Community Access -- Teledemocracy in the Province: An Experiment with Internet-Based Software and Public Debate -- Part Four: (Business) Opportunities on the Net -- Work and Community in Networked Organizations -- ICTs for SMEs: The SME Wins on the Information Highway -- The Centre for Editing Early Canadian Texts (CEECT) and Cyberspace -- Part Five: The Role of Government --; The Position of Flanders with Regard to Some Internet-Related Matters -- Québécois Policy and the Development of the Information Highway -- Advancing Canada's Information Highway: Strategies for the New Millennium -- Electronic Commerce Policy and the European Commission.
• Sommario/riassunto: This innovative study explores diverse aspects of Canadian and European identity on the information highway and reaches beyond technical issues to confront and explore communication, culture and the culture of communication.