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Record Nr. |
UNINA9910138868603321 |
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Autore |
Dörwald Florencio Zaragoza |
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Titolo |
Lead optimization for medicinal chemists [[electronic resource] ] : pharmacokinetic properties of functional groups and organic compounds / / Florencio Zaragoza Dörwald |
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Pubbl/distr/stampa |
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Weinheim, Germany, : Wiley-VCH, 2012 |
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ISBN |
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3-527-64564-0 |
1-283-89324-X |
3-527-64566-7 |
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Descrizione fisica |
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1 online resource (623 p.) |
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Disciplina |
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Soggetti |
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Pharmacokinetics |
Drug development |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Description based upon print version of record. |
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Nota di bibliografia |
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Includes bibliographical references and index. |
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Nota di contenuto |
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pt. 1. Introduction -- pt. 2. The pharmacokinetic properties of compound classes. |
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Sommario/riassunto |
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Small structural modifications can significantly affect the pharmacokinetic properties of drug candidates. This book, written by a medicinal chemist for medicinal chemists, is a comprehensive guide to the pharmacokinetic impact of functional groups, the pharmacokinetic optimization of drug leads, and an exhaustive collection of pharmacokinetic data, arranged according to the structure of the drug, not its target or indication. The historical origins of most drug classes and general aspects of modern drug discovery and development are also discussed. The index contains all the drug names and sy |
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