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Record Nr. |
UNINA9910137530103321 |
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Autore |
Kezhong Zhang |
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Titolo |
Endoplasmic reticulum stress response and transcriptional reprogramming / / topic editor Kezhong Zhang |
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Pubbl/distr/stampa |
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Frontiers Media SA, 2015 |
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Switzerland : , : Frontiers Media SA, , 2015 |
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ISBN |
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Descrizione fisica |
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1 online resource (97 pages) : illustrations |
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Collana |
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Frontiers Research Topics |
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Soggetti |
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Cytology |
Biology |
Health & Biological Sciences |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Bibliographic Level Mode of Issuance: Monograph |
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Nota di bibliografia |
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Includes bibliographical references. |
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Sommario/riassunto |
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Endoplasmic reticulum (ER) is an intracellular organelle responsible for protein folding and assembly, lipid and sterol biosynthesis, and calcium storage. A number of biochemical, physiological, or pathological stimuli can interrupt protein folding process, causing accumulation of unfolded or misfolded proteins in the ER lumen, a condition called “ER stress”. To cope with accumulation of unfolded or misfolded proteins, the ER has evolved a group of signaling pathways termed “Unfolded Protein Response (UPR)” or “ER stress response” to align cellular physiology. To maintain ER homeostasis, transcriptional regulation mediated through multiple UPR branches is orchestrated to increase ER folding capacity, reduce ER workload, and promote degradation of misfolded proteins. In recent years, accumulating evidence suggests that ER stress-triggered transcriptional reprogramming exists in many pathophysiological processes and plays fundamental roles in the initiation and progression of a variety of diseases, such as metabolic disease, cardiovascular disease, neurodegenerative disease, and cancer. Understanding effects and mechanisms of ER stress-associated transcriptional reprogramming has high impact on many areas of molecular genetics and will be particularly informative to the |
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development of pharmacologic avenues towards the prevention and treatment of modern common human diseases by targeting the UPR signaling. For these reasons, ER stress response and transcriptional reprogramming are a timely and necessary topic of discussion for Frontiers in Genetics. |
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2. |
Record Nr. |
UNINA9910970549203321 |
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Titolo |
Communication and power in the global era : orders and borders / / edited by Marwan M. Kraidy |
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Pubbl/distr/stampa |
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London ; ; New York : , : Routledge, , 2013 |
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ISBN |
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1-136-23831-X |
0-203-10207-X |
1-283-86178-X |
1-136-23832-8 |
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Edizione |
[1st ed.] |
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Descrizione fisica |
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1 online resource (202 p.) |
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Collana |
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Shaping inquiry in culture, communication and media studies |
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Classificazione |
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Altri autori (Persone) |
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Disciplina |
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Soggetti |
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Communication, International |
Mass media and globalization |
Mass media - Social aspects |
Mass media - Political aspects |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Description based upon print version of record. |
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Nota di bibliografia |
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Includes bibliographical references and index. |
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Nota di contenuto |
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pt. I. Ordering borders : the transnational management of subjectivity -- pt. II. Branding nations : re-imagining communities in neo-liberal states -- pt. III. Being modern : situating the grand narrative -- pt. IV. Destabilizing orders : resistance and social transformation. |
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Sommario/riassunto |
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"This book re-visits how we think about communication and power in the global era. It takes stock of the last fifty years of scholarship, maps key patterns and concepts and sets an agenda for theory and research. The book addresses such questions as:How are national and cultural identities re-fashioned and expressed in the global era?How can we best understand the emergence of multiple and sometimes antagonistic |
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modernities worldwide?How are political struggles fought and communicated on the local-national-global nexus? How do we integrate emerging media environments in global communication studies?Bringing together essays from a range of internationally renowned scholars, this book will be useful to undergraduate and postgraduate students on Media and Communication Studies courses, particularly those studying globalisation and global media.Contributors: Hector Amaya Paula Chakravartty Andrew Crocco Myria Georgiou Le Han Anikó Imre Koichi Iwabuchi Marwan M. Kraidy Sara Mourad Patrick D. Murphy Tarik Sabry Paddy Scannell Piotr M. Szpunar Guobin Yang Barbie Zelizer "-- |
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