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Record Nr. |
UNINA9910137221703321 |
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Autore |
Jesus Avila |
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Titolo |
Tau oligomers / / topic editors, Naruhiko Sahara and Jesus Avila |
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Pubbl/distr/stampa |
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Frontiers Media SA, 2014 |
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[Lausanne, Switzerland] : , : Frontiers Media SA, , 2014 |
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ISBN |
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Descrizione fisica |
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1 online resource (113 pages) : illustrations; digital, PDF file(s) |
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Collana |
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Frontiers Research Topics |
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Soggetti |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Nota di bibliografia |
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Includes bibliographical references. |
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Sommario/riassunto |
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Neurofibrillary tangles (NFTs) composed of intracellular aggregates of tau protein are a key neuropathological feature of Alzheimer’s Disease (AD) and other neurodegenerative diseases, collectively termed tauopathies. The abundance of NFTs has been reported to correlate positively with the severity of cognitive impairment in AD. However, accumulating evidences derived from studies of experimental models have identified that NFTs themselves may not be neurotoxic. Now, many of tau researchers are seeking a “toxic” form of tau protein. Moreover, it was suggested that a “toxic” tau was capable to seed aggregation of native tau protein and to propagate in a prion-like manner. However, the exact neurotoxic tau species remain unclear. Because mature tangles seem to be non-toxic component, “tau oligomers” as the candidate of “toxic” tau have been investigated for more than one decade. In this topic, we will discuss our consensus of “tau oligomers” because the term of “tau oligomers” [e.g. dimer (disulfide bond-dependent or independent), multimer (more than dimer), granular (definition by EM or AFM) and maybe small filamentous aggregates] has been used by each researchers definition. From a biochemical point of view, tau protein has several unique characteristics such as natively unfolded conformation, thermo-stability, acid-stability, and capability of post-translational modifications. Although tau protein research has been continued for a |
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long time, we are still missing the mechanisms of NFT formation. It is unclear how the conversion is occurred from natively unfolded protein to abnormally mis-folded protein. It remains unknown how tau protein can be formed filaments [e.g. paired helical filament (PHF), straight filament and twisted filament] in cells albeit in vitro studies confirmed tau self-assembly by several inducing factors. Researchers are still debating whether tau oligomerization is primary event rather than tau phosphorylation in the tau pathogenesis. Inhibition of either tau phosphorylation or aggregation has been investigated for the prevention of tauopathies, however, it will make an irrelevant result if we don’t know an exact target of neurotoxicity. It is a time to have a consensus of definition, terminology and methodology for the identification of “tau oligomers”. |
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2. |
Record Nr. |
UNINA9910845487003321 |
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Titolo |
Being Participatory: Researching with Children and Young People : Co-constructing Knowledge Using Creative, Digital and Innovative Techniques / / edited by Imelda Coyne, Bernie Carter |
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Pubbl/distr/stampa |
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Cham : , : Springer International Publishing : , : Imprint : Springer, , 2024 |
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ISBN |
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Edizione |
[2nd ed. 2024.] |
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Descrizione fisica |
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1 online resource (267 pages) |
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Disciplina |
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Soggetti |
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Nursing services - Administration |
Nursing - Research |
Developmental psychology |
Pediatrics |
Quality of life |
Internal medicine |
Nursing Management |
Nursing Research |
Child and Adolescence Psychology |
Quality of Life Research |
Internal Medicine |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Nota di bibliografia |
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Includes bibliographical references. |
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Nota di contenuto |
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Chapter 1. Participatory Research in the Past, Present and Future -- Chapter 2. Principles of Participatory Research -- Chapter 3. Ethical Issues in Participatory Research with Children and Young People -- Chapter 4. Contribution of Participatory Research with Children and Young People to Policy -- Chapter 5. Being Participatory Through Play -- Chapter 6. Being Participatory Through Interviews -- Chapter 7. Being Participatory Through Photo-Based Images -- Chapter 8. Being Participatory Through the Use of App-Based Research Tools -- Chapter 9. Being participatory through animation -- Chapter 10. Being participatory through videography -- Chapter 11. Does Participatory Research Genuinely Extend the Sphere of Participation for Children and Young People?. |
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Sommario/riassunto |
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The second edition of this book provides a clear framework for conducting participatory research with children and young people supported by practical examples from international research studies. Our aim is to encourage more participatory research with children and young people on all matters that affect their lives. This book illustrates innovative ways of being participatory and how such methods can promote the inclusion of children and young people with diverse experiences and backgrounds. It sheds new light on involvement strategies that recognise agency and that play to children and young people's strengths. The international experts in this book share knowledge built from their wealth of experience in undertaking participatory research with children and young people using creative techniques that can enable and promote ways of expressing their views and experiences. The book provides guidance on appropriate techniques that can reduce the power differential between adult researchers and children and young people as participants. These techniques help to optimise their abilities to participate in research. There is increasing interest in involving children and young people as co-researchers but little guidance on how this can be done. This book fills a gap in the current literature by addressing all these issues outlined above and by providing worked examples from leading researchers and academics. Building on the success of the first edition and, with an additional three chapters, this second edition is sure to have wide appeal to researchers across a range of different disciplines. This book is targeted at researchers, academics, and practitioners who need guidance on what tools are available, how the tools can be used, advantages and challenges, and how best to involve children and young people in all stages of a research project. |
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