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1. |
Record Nr. |
UNINA9910137088903321 |
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Autore |
Elise Dumont |
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Titolo |
Radiation-induced and oxidative DNA damages |
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Pubbl/distr/stampa |
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Descrizione fisica |
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1 online resource (93 p.) |
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Collana |
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Frontiers Research Topics |
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Soggetti |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Sommario/riassunto |
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DNA stores and passes the genetic information of almost all living organisms. Its molecular structure and their intramolecular interactions are particularly suitable to maximize stability against oxidative stress and UV-light absorption. Yet the protection and repair strategies are still error-prone: DNA lesions are produced, including the most complex and highly mutagenic ones. An important threat to DNA stability comes from photosensitization, i.e. from the dramatic multiplication of radiation-induced defects mediated by the presence of organic or organometallic dyes compared to the direct exposure to UVA radiation. Moreover, the photo-induced production of singlet oxygen generates an extremely high oxidative stress on DNA that, in vivo, normally results in extended cellular apoptosis. Elucidating the processes leading to DNA damages, from the production of a simple radical entity to deleterious lesions, as well as the opportunities of repair by devoted enzymes, is a cornerstone towards the development of more efficient protection strategies. Sensitization and selective production of DNA lesions can also be exploited to induce the selective apoptosis of cancer cells upon exposition to radiation or to oxidative stress, for instance in the field of photodynamic therapy. The importance and relevance of the field is witnessed by the impressive amount of high-level papers dealing with this complex subject, and notably tackling the structural elucidation of DNA and DNA-drug adducts, the mechanisms of formation of DNA lesions (including the |
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precise detection of the final lesion products), as well as the influence of the lesions on the DNA stability and dynamics and the consequences on the ease of repair. Due to the complexity of the field lying at the frontiers between chemistry, physics and biology, multidisciplinary strategies allying modeling and experience are needed. This topic aims at giving an extended overview of the current research in the domain, with fundamental contribution from the leading groups in the field of DNA reactivity, structural characterization, photo-chemistry and photo-physics, as well as repair mechanism. It will therefore be a fundamental guide for scientists wanting to address the field of DNA lesion and repair, but also more generally for researchers working in rational drug design or in the development of biomarkers and medical imaging techniques. |
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2. |
Record Nr. |
UNINA9910139972303321 |
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Autore |
Massicard Élise |
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Titolo |
Les élections du 3 novembre 2002 : une recomposition de la vie politique turque |
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Pubbl/distr/stampa |
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Institut français d’études anatoliennes, 2003 |
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[Place of publication not identified], : Institut français d'études anatoliennes, 2003 |
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ISBN |
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Descrizione fisica |
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1 online resource (49 pages) |
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Collana |
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Dossiers de l'IFEA. Série La Turquie aujourd'hui ; ; Numéro 15 |
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Soggetti |
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Government - Non-U.S |
Law, Politics & Government |
Government - Asia |
Turkey Politics and government |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Bibliographic Level Mode of Issuance: Monograph |
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Nota di bibliografia |
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Includes bibliographical references. |
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Sommario/riassunto |
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Ce dossier analyse les résultats du scrutin de novembre 2002, voyant s'il y a lieu de souscrire à l'interprétation dominante du « raz-de-marée |
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» largement relayée dans la presse nationale et internationale. Au-delà des résultats sont mis en question les pratiques politiques, la manière dont se joue la compétition électorale, et le système électoral en Turquie dans son ensemble. Il s'interroge également sur la signification de ces élections dans le contexte général de la Turquie contemporaine. |
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