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Record Nr. |
UNINA9910136799803321 |
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Autore |
Pedro Viana Baptista |
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Titolo |
Cancer nanotheranostics : what have we learned so far? / / edited by João Conde, Pedro Viana Baptista, Jesús M. De La Fuente and Furong Tian |
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Pubbl/distr/stampa |
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Frontiers Media SA, 2016 |
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[Lausanne, Switzerland] : , : Frontiers Media SA, , [2015] |
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©2015 |
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ISBN |
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Descrizione fisica |
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1 online resource (128 pages) : illustrations (chiefly colour); digital file(s) |
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Collana |
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Frontiers in Chemistry |
Frontiers Research Topics |
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Disciplina |
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Soggetti |
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Cancer - Treatment |
Nanostructured materials - Health aspects |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Nota di bibliografia |
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Includes bibliographical references. |
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Sommario/riassunto |
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After a quarter of century of rapid technological advances, research has revealed the complexity of cancer, a disease intimately related to the dynamic transformation of the genome. However, the full understanding of the molecular onset of this disease is still far from achieved and the search for mechanisms of treatment will follow closely. It is here that Nanotechnology enters the fray offering a wealth of tools to diagnose and treat cancer. In fact, the National Cancer Institute predicts that over the next years, nanotechnology will result in important advances in early detection, molecular imaging, targeted and multifunctional therapeutics, prevention and control of cancer. Nanotechnology offers numerous tools to diagnose and treat cancer, such as new imaging agents, multifunctional devices capable of overcome biological barriers to deliver therapeutic agents directly to cells and tissues involved in cancer growth and metastasis, and devices capable of predicting molecular changes to prevent action against precancerous cells... Nevertheless, despite the significant efforts |
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towards the use of nanomaterials in biologically relevant research, more in vivo studies are needed to assess the applicability of these materials as delivery agents. In fact, only a few went through feasible clinical trials. Nanomaterials have to serve as the norm rather than an exception in the future conventional cancer treatments. Future in vivo work will need to carefully consider the correct choice of chemical modifications to incorporate into the multifunctional nanocarriers to avoid activation off-target, side effects and toxicity. Moreover the majority of studies on nanomaterials do not consider the final application to guide the design of nanomaterial. Instead, the focus is predominantly on engineering materials with specific physical or chemical properties. It is imperative to learn how advances in nanosystem’s capabilities are being used to identify new diagnostic and therapy tools driving the development of personalized medicine in oncology; discover how integrating cancer research and nanotechnology modeling can help patient diagnosis and treatment; recognize how to translate nanotheranostics data into an actionable clinical strategy; discuss with industry leaders how nanotheranostics is evolving and what the impact is on current research efforts; and last but not least, learn what approaches are proving fruitful in turning promising clinical data into treatment realities. |
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2. |
Record Nr. |
UNINA9910272354403321 |
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Autore |
Corngold Stanley |
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Titolo |
Franz Kafka : The Necessity of Form / / Stanley Corngold |
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Pubbl/distr/stampa |
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Cornell University Press, 2018 |
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Ithaca, NY : , : Cornell University Press, , [2018] |
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©1990 |
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ISBN |
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Descrizione fisica |
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1 online resource (321 pages) |
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Disciplina |
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Soggetti |
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Authors, Austrian - 20th century |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Nota di contenuto |
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Frontmatter -- Contents -- Preface -- Acknowledgments -- Abbreviations for Kafka Citations -- Introduction -- PART I KAFKA'S CAREER -- PART II Kafka's C ontext -- Excursus on Method -- Index |
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Sommario/riassunto |
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In Stanley Corngold's view, the themes and strategies of Kafka's fiction are generated by a tension between his concern for writing and his growing sense of its arbitrary character. Analyzing Kafka's work in light of "the necessity of form," which is also a merely formal necessity, Corngold uncovers the fundamental paradox of Kafka's art and life. The first section of the book shows how Kafka's rhetoric may be understood as the daring project of a man compelled to live his life as literature. In the central part of the book, Corngold reflects on the place of Kafka within the modern tradition, discussing such influential precursors of Cervantes, Flaubert, and Nietzsche, whose works display a comparable narrative disruption. Kafka's distinctive narrative strategies, Corngold points out, demand interpretation at the same time they resist it. Critics of Kafka, he says, must be aware that their approaches are guided by the principles that Kafka's fiction identifies, dramatizes, and rejects. |
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