Hydrothermal enrichment of gallium in zones of advanced argillic alteration, examples from the Paradise Peak and McDermitt ore deposits, Nevada [[electronic resource] /] / by James J. Rytuba ... [and others]

• Record Nr.: UNINA9910695248003321
• Autore: Rytuba James J
• Pubbl/distr/stampa: [Reston, Va.] : , : U.S. Dept. of the Interior, U.S. Geological Survey, , [2003]
• Edizione: [Version 1.0, 2003.]
• Descrizione fisica: iii, 16 pages : digital, PDF file
• Collana: Bulletin / U.S. Department of the Interior, U.S. Geological Survey ; ; 2209-C.; Chapter C of Contributions to industrial-minerals research
• Altri autori (Persone): BlissJames D; MoylePhillip R; LongKeith R
• Soggetti: Gallium - Nevada; Hydrothermal deposits - Nevada; Ore deposits - Nevada - McDermitt Mine; Ore deposits - Nevada - Paradise Peak Mine; McDermitt Mine (Nev.); Paradise Peak Mine (Nev.)
• Lingua di pubblicazione: Inglese
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Note generali: Title from title screen (viewed on Aug. 23, 2006).; "James D. Bliss, Phillip R. Moyle, and Keith R. Long, editors."
• Nota di bibliografia: Includes bibliographical references (pages 15-16).

The Schistosomiasis Vaccine - It Is Time to Stand Up

• Record Nr.: UNINA9910136798703321
• Autore: Ahmad Ali Othman
• Pubbl/distr/stampa: Frontiers Media SA, 2015
• Descrizione fisica: 1 online resource (82 p.)
• Collana: Frontiers Research Topics
• Soggetti: Medicine and Nursing
• Lingua di pubblicazione: Inglese
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Sommario/riassunto: Schistosomiasis is a severe parasitic disease, endemic in 74 developing countries with up to 600 million people, including many children, infected and 800 million at risk of contracting the disease following infection with Schistosoma mansoni, S. haematobium or S. japonicum. Disease burden is estimated to exceed 70 million disability-adjusted life-years, and leads to remarkably high YLD (years lived with disability) rates. Even more importantly, people with schistosomiasis are highly susceptible to malaria, tuberculosis and hepatic and acquired immunodeficiency viruses. There is only one drug, praziquantel, currently available for treatment and it has high efficacy, low cost, and limited side effects. However, only 13% of the target population has received the drug, and those treated are at continuous risk of reinfection necessitating repeated drug administration and the emergence of drug resistant parasites is a constant threat. There currently is no vaccine. While the target of >40% protection has been achieved with some molecules such as excretory-secretory proteins including calpain, glyceraldehyde 3-phosphate dehydrogenase, and cysteine peptidases, very recent articles reiterate the findings published during the last 2 decades of the last century, contradicting the established data of the pioneers of schistosome biology. A consensus should be reached without delay, in order to propose collaborative independent experiments and proceed ahead to pre- and clinical trials with efficacious candidate vaccine molecules. The proposed plan aims ; to finally reach an objective and fruitful agreement , via inviting established and young researchers from the United States, Brazil, China, Australia, and Europe who are working with different vaccine antigens, adjuvants, and approaches for immunization against S. mansoni, S. haematobium, and S. japonicum. It is hoped that the forum will end with a very few candidate antigens and a consensus approach regarding target immune responses, thus leading to encouraging the World Health Organization and other international foundations to sponsor the development and implementation of the urgently required, yet still elusive, vaccine for preventing and eliminating the transmission of schistosomiasis.