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1. |
Record Nr. |
UNINA9910136508903321 |
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Autore |
Bounds E. M. |
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Titolo |
The necessity of prayer / / E. M. Bounds |
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Pubbl/distr/stampa |
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[Place of publication not identified] : , : Dancing Unicorn Books, , 2016 |
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ISBN |
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Descrizione fisica |
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1 online resource (79 p.) |
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Disciplina |
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Soggetti |
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Prayer |
Prayer - Biblical teaching |
Prayer - Christianity |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Description based upon print version of record. |
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Nota di contenuto |
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Foreword; Prayer and Faith; Prayer and Trust; Prayer and Desire; Prayer and Fervency; Prayer and Importunity; Prayer and Importunity (Continued); Prayer and Character and Conduct; Prayer and Obedience; Prayer and Obedience (Continued); Prayer and Vigilance; Prayer and the Word of God; Prayer and the Word of God (Continued); Prayer and the House of God |
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Sommario/riassunto |
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In any study of the principles, and procedure of prayer, of its activities and enterprises, first place, must, of necessity, be given to faith. It is the initial quality in the heart of any man who essays to talk to the Unseen. He must, out of sheer helplessness, stretch forth hands of faith. He must believe, where he cannot prove. In the ultimate issue, prayer is simply faith, claiming its natural yet marvellous prerogatives - faith taking possession of its illimitable inheritance. True godliness is just as true, steady, and persevering in the realm of faith as it is in the province of prayer |
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2. |
Record Nr. |
UNINA9910591045203321 |
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Autore |
Bidaud Camille |
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Titolo |
La parcelle dans tous ses états / / Florence Bourillon, Corinne Jaquand |
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Pubbl/distr/stampa |
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Rennes, : Presses universitaires de Rennes, 2022 |
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ISBN |
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Descrizione fisica |
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1 online resource (262 p.) |
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Collana |
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Altri autori (Persone) |
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BocquetDenis |
BourillonFlorence |
ErrardPaul-Édouard |
GressetPhilippe |
GrudetIsabelle |
JaquandCorinne |
JourdheuilAnne-Laure |
LaffontJean-Luc |
Lambert-BressonMichèle |
LecatPaul |
Le BourhisEric |
PerlussPreston |
PugetJulien |
SchoonbaertSylvain |
SecciClaudio |
SowaCharline |
ThiardPhilippe |
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Soggetti |
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Urban Studies |
History |
morphologie urbaine |
zonage |
foncier |
remembrement |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Sommario/riassunto |
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La parcelle en ville est un objet historique qui s’inscrit dans le temps long sous diverses appellations. À la fois projection au sol d’un rapport de propriété légal ou coutumier et « petite partie d’un tout » à des fins d’exploitation et d’investissement, elle est propice aux approches pluridisciplinaires. Son étude renvoie en effet à la question cruciale du changement urbain, mais aussi aux idéologies politiques et modernistes à l’encontre du droit de propriété qui ont pu entraîner sa remise en cause au xxe siècle, comme en URSS et dans les États socialistes ou dans les ensembles d’habitat collectif de l’entre-deux-guerres et des Trente Glorieuses. À rebours, elle constitue un enjeu prégnant dans les projets urbains contemporains, sans que d’ailleurs les discours développés à son sujet ne fassent toujours l’objet de questionnements approfondis. Cet ouvrage se propose de reconstituer l’histoire longue de la parcelle car elle est susceptible de rendre compte, à bien des égards, des transformations contemporaines. |
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3. |
Record Nr. |
UNINA9910136406903321 |
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Autore |
Michel Alexander Steiner |
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Titolo |
Insomnia and beyond - Exploring the therapeutic potential of orexin receptor antagonists |
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Pubbl/distr/stampa |
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Descrizione fisica |
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1 online resource (219 p.) |
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Collana |
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Frontiers Research Topics |
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Soggetti |
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Neurology and clinical neurophysiology |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Sommario/riassunto |
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Orexin/hypocretin neuropeptides, produced by a few thousand neurons in the lateral hypothalamus, are of critical importance for the control of vigilance and arousal of vertebrates, from fish to amphibians, birds and mammals. Two orexin peptides, called orexin-A and orexin-B, exist in mammals. They bind with different affinities to two distinct, widely distributed, excitatory G-protein- coupled receptors, orexin receptor |
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type 1 and type 2 (OXR-1/2). The discovery of an OXR mutation causing canine narcolepsy, the narcolepsy-like phenotype of orexin peptide knockout mice, and the orexin neuron loss associated with human narcoleptic patients laid the foundation for the discovery of small molecule OXR antagonists as novel treatments for sleep disorders. Proof of concept studies from Glaxo Smith Kline, Actelion Pharmaceuticals Ltd. and Merck have now consistently demonstrated the efficacy of dual OXR antagonists (DORAs) in promoting sleep in rodents, dogs, non-human primates and humans. Some of these antagonists have completed late stage clinical testing in primary insomnia. Orexin drug discovery programs have also been initiated by other large pharmaceutical companies including Hoffmann La Roche, Novartis, Eli Lilly and Johnson & Johnson. Orexins are increasingly recognized for orchestrating the activity of the organism's arousal system with appetite, reward and stress processing pathways. Therefore, in addition to models of insomnia, pharmacological effects of DORAs have begun to be investigated in rodent models of addiction, depression and anxiety. The first clinical trials in diabetic neuropathy, migraine and depression have been initiated with Merck's MK-6096 (www.clinicaltrials.gov). Whereas the pharmacology of DORAs is established for their effects on wakefulness, pharmacological effects of selective OXR-1 or OXR-2 antagonists (SORAs) have remained less clear. From an evolutionary point of view, the OXR-2 was expressed first in most vertebrate lineages, whereas the OXR-1 is believed to result from a gene duplication event, when mammals emerged. Yet, both receptors do not have redundant function. Their brain expression pattern, their intracellular signaling, as well as their affinity for orexin-A and orexin-B differs. During the past decade most preclinical research on selective OXR-1 antagonism was performed with SB-334867. Only in recent years, other selective OXR-1 and OXR-2 antagonists with optimized selectivity profiles and pharmacokinetic properties have been discovered, and phenotypes of OXR-1 and OXR-2 knockout mice were described. The present Research Topic (referred to in the Editorial as "special topics issue") comprises submissions of original research manuscripts as well as reviews, directed towards the neuropharmacology of OXR antagonists. The submissions are preclinical papers dealing with dual and/or selective OXR antagonists that shed light on the differential contribution of endogenous orexin signaling through both OXRs for cellular, physiological and behavioral processes. Some manuscripts also report on convergence or divergence of DORA vs. SORA effects with phenotypes expressed by OXR-1 or OXR-2 knockout animals. Ultimately these findings may help further define the potential of DORAs and SORAs in particular therapeutic areas in insomnia and beyond insomnia. |
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