Host - pathogen interaction : microbial metabolism, pathogenicity and antiinfectives / / edited by Gottfried Unden, Eckhard Thines, and Anja Schüffler

• Record Nr.: UNINA9910136459603321
• Pubbl/distr/stampa: Weinheim, Germany : , : Wiley-VCH Verlag GmbH & Company KGaA, , 2016; ©2016
• ISBN: 3-527-68241-4; 3-527-68238-4; 3-527-68239-2
• Descrizione fisica: 1 online resource (237 pages.)
• Collana: Drug discovery in infectious diseases
• Disciplina: 577.857
• Soggetti: Host-parasite relationships; Communicable diseases; Infection; Pathogenic microorganisms; Anti-infective agents
• Lingua di pubblicazione: Inglese
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Note generali: Description based upon print version of record.
• Nota di bibliografia: Includes bibliographical references and index.
• Nota di contenuto: Cover; Title Page; Copyright; Contents; Preface; Cover Legend; List of Contributors; Part One Adaptation of Microbial Metabolism in Host/Pathogen Interaction; Chapter 1 Metabolic Adaptation of Human Pathogenic Yersiniae; Introduction; Yersinia Life Cycles and Pathogenesis; Carbon Metabolism and Links to Yersinia Pathogenesis; Food Sources, Nutrient Sequestration, and Utilization; Metabolic Pathways of Yersinia Crucial for Virulence; Nutritional Virulence: Nutritional Adaptation Important for Pathogenesis; Coordinated Control of Carbon Metabolism and Virulence; Importance of Ions; Importance of the Csr SystemImportance of CCR and the cAMP-Crp Complex; Importance of Posttranscriptional Regulation Strategies; Conclusions; Acknowledgments; References; Chapter 2 Crosstalk between Metabolism and Virulence of Legionella pneumophila; Introduction; Key Metabolic Features of L. pneumophila; Serine and ; Glucose Metabolism of L. pneumophila under In Vitro Conditions; Metabolism of L. pneumophila under Intracellular Conditions; Metabolic Adaptation during the Life Cycle of Intracellular L. pneumophila; Metabolic Host Cell Responses Triggered by Intracellular L. pneumophila; ConclusionReferences; Chapter 3 Metabolism of Intracellular Salmonella enterica; Introduction; S. enterica-A Metabolic Generalist; Metabolism of Glucose by S. enterica; Connection to the TCA Cycle by Oxidative Decarboxylation of Pyruvate; The Important Role of the TCA Cycle and Anaplerotic Reactions; Metabolism of Intracellular S. enterica; The Metabolism of S. enterica Compared to Other Important Intracellular and Gastrointestinal Pathogens; Salmonella Induce Networks of Tubular Structures-Access to Host-Derived Nutrients?; S. enterica Has a Bimodal Lifestyle in Epithelial Cells; Salmonella Metabolism Limits Possibilities for New AntimicrobialsConclusions; References; Chapter 4 The Human Microbiome in Health and Disease; Introduction; Methods for Characterizing the Microbiota; Diet and Geographical Factors; Functional Gastrointestinal Disorders; Manipulation of the Microbiota; Conclusions; Acknowledgments; References; Chapter 5 Mechanisms of Dysbiosis in the Inflamed Gut; Introduction; Dysbiosis during Inflammatory Diseases of the Gastrointestinal Tract; Nutrient Acquisition by Commensal Bacteria in the Normal Gut; Nutritional Mechanisms for Dysbiosis in the Inflamed GutInflammation-Driven Bloom of Enteric Pathogens in the Gut Lumen; How Anaerobic Respiration Enhances Growth in the Inflamed Gut; Conclusions; References; Chapter 6 Strategies for Nutrient Acquisition by Magnaporthe oryzae during the Infection of Rice; Introduction; Adhesion and Germination; Appressorium Formation; Penetration; Growth in Planta: The Biotrophic Growth Phase; Growth in Planta: Necrotrophic Growth Phase; Growth in Planta: Sporulation; Life Outside of the Rice Plant; Conclusion; References; Part Two New Inhibitors and Targets of Infectious Diseases