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1. |
Record Nr. |
UNINA990004194560403321 |
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Autore |
International Association of Hispanists |
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Titolo |
Actas del XII Congreso de la Asociación internacional de hispanistas : 21 - 26 de agosto de 1995, Birmingham |
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Pubbl/distr/stampa |
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Birmingham : Department of hispanic studies, The University of Birmingham, 1998 |
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Descrizione fisica |
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Disciplina |
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Locazione |
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Collocazione |
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860.9 AIH 1(1) |
860.9 AIH 1(2) |
860.9 AIH 1(3) |
860.9 AIH 1(4) |
860.9 AIH 1(5) |
860.9 AIH 1(6) |
860.9 AIH 1(7) |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Nota di contenuto |
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1.: Medieval y lingüistica / edición al cuidado de Aengus M. Ward 2.: Estudios áureos, 1. / edición al cuidado de Jules Whicker 3.: Estudios áureos, 2. / edición al cuidado de Jules Whicker 4.: Estudios hispanoamericanos 1. / edición al cuidado de Trevor J. Dadson 5.: Epoca contemporanea / edición al cuidado de Derek W. Flitter 6.: Del romanticismo a la guerra civil / edición al cuidado de Derek W. Flitter 7.: Estudios hispanoamericanos 2. / edición al cuidado de Patricia Odber de Baubeta |
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2. |
Record Nr. |
UNINA9910648800403321 |
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Autore |
Dillery, John |
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Titolo |
Clio's other sons : Berossus and Manetho : with an afterword on Demetrius / John Dillery |
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Pubbl/distr/stampa |
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Ann Arbor, : University of Michigan Press, 2015 |
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ISBN |
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Descrizione fisica |
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Locazione |
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Collocazione |
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Fonti II Berossus e Manetho St. 5 |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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3. |
Record Nr. |
UNINA9910707259403321 |
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Autore |
Gott Garland B (Garland Bayard), <1912-1996, > |
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Titolo |
Geology of the Edgemont N E quadrangle, Fall River and Custer Counties, South Dakota / / by Garland B. Gott and Robert W. Schnapel |
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Pubbl/distr/stampa |
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Washington, D.C. : , : United States Department of the Interior, Geological Survey, , 1963 |
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Washington, D.C. : , : Government Printing Office |
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Descrizione fisica |
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1 online resource (v, 127-190 pages, 5 pages of plates) : maps, charts |
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Collana |
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Geological Survey bulletin ; ; 1063-E |
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Soggetti |
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Geology - South Dakota - Fall River County |
Geology - South Dakota - Custer County |
Geology |
South Dakota Custer County |
South Dakota Fall River County |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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"Prepared on behalf of the U. S. Atomic Energy Commission." |
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Title from title screen (viewed July 23, 2014). |
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Nota di bibliografia |
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Includes bibliographical references (pages 186-188) and index. |
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4. |
Record Nr. |
UNINA9910136401003321 |
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Autore |
Cristina Bonorino |
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Titolo |
The immunology of cellular stress proteins |
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Pubbl/distr/stampa |
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Descrizione fisica |
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1 online resource (89 p.) |
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Collana |
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Frontiers Research Topics |
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Soggetti |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Sommario/riassunto |
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Stress proteins or heat-shock proteins (HSP) are evolutionary conserved proteins present in every prokaryotic and eukaryotic cell. Their main function is to protect cells and proteins from damage under stressful circumstances. The latter circumstances do include the cell and protein damaging effects of inflammation. The discovery of mycobacterial HSP60 being a critical antigen in the model of adjuvant arthritis, has led to studies that showed the immuno-dominance of microbial HSP60 and the potential of the microbial HSP induced repertoire of antibodies and T cells to cross-recognize the self-HSP homologues of stressed cells. Since then, the research in the immunology of stress proteins started to comprise a widening spectrum of topics with potential medical relevance. Interestingly, since stress proteins have their activities in both innate and adaptive immunity, they are key elements in the cross-roads between both arms of the immune system. Stress proteins or HSP can be considered as functional 'biomarkers' of inflammation. They are up-regulated locally during inflammation and interestingly, they seem to function as targets for anti-inflammatory regulatory T cells. In experimental models of autoimmunity, mainly arthritis, administration of HSP peptides have been shown to suppress disease. First clinical trials have shown the anti-inflammatory nature of T cell responses to |
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Hsp. In type I diabetes and in rheumatoid arthritis, parenteral and oral administration of Hsp peptides were shown to induce a bias in pro-inflammatory T cells, switching them in the direction of regulatory cytokine production (IL4, IL5 and IL10). In addition a raised level of a marker of natural T regulatory cells, the transcription factor FoxP3, was noted in the RA trial. Other inflammatory diseases or diseases with inflammatory components which feature the immune imprint of the up-regulated Hsp are atherosclerosis, inflammatory bowel diseases, multiple sclerosis and atopic diseases such atopic dermatitis and allergic asthma. |
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