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Record Nr. |
UNINA9910136389803321 |
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Autore |
Alejandro Garcia Carranca |
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Titolo |
Epigenetic modifications and viral infections / / edited by Silvia Carolina Galvan, Alejandro García Carrancá, Félix Recillas-Targa and Jiuzhou Song |
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Pubbl/distr/stampa |
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Frontiers Media SA, 2015 |
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Switzerland : , : Frontiers Media SA, , 2015 |
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ISBN |
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Descrizione fisica |
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1 online resource (111 pages) : illustrations |
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Collana |
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Frontiers Research Topics |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Nota di bibliografia |
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Includes bibliographical references. |
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Sommario/riassunto |
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Epigenetics is defined as the study of modifications of the genome, heritable during cell division that does not involve changes in DNA sequences. Up to date, epigenetic modifications involve at least three general mechanisms regulating gene expression: histone modifications, DNA methylation, and non-coding RNAs (ncRNAs).For the past two decades, an explosion in our interest and understanding of epigenetic mechanisms has been seen. This mainly based on the influence that epigenetic alterations have on an amazing number of biological processes, such as gene expression, imprinting, programmed DNA rearrangements, germ line silencing, developmentally cued stem cell division, and overall chromosomal stability and identity.It has become also evident that the constant exposure of living organisms to environment factors affects their genomes through epigenetic mechanisms. Viruses infecting animal cells are thought to play central roles in shaping the epigenetic scenario of infected cells. In this context it has become obvious that knowing the impact that viral infections have on the epigenetic control of their host cells will certainly lead to a better understanding of the interplay viruses have with animal cells.In fact, DNA viruses use host transcription factors as well as epigenetic regulators in such a way that they affect epigenetic control of gene |
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expression that extends to host gene expression. At the same time, animal cells employ mechanisms controlling transcription factors and epigenetic processes, in order to eliminate viral infections. In summary, epigenetic mechanisms are involved in most virus-cell interactions.We now know that some viruses exhibit epigenetic immune evasion mechanisms to survive and propagate in their host; however, there is still much ambiguity over these epigenetic mechanisms of viral immune evasion, and most of the discovered mechanisms are still incomplete. Other animal viruses associated to cancer often deregulate cellular epigenetic mechanisms, silencing cellular tumor-suppressor genes and/or activating either viral or host cell oncogenes. In addition, in several cancers the down-regulation of tumor suppressor protein-coding genes and ncRNAs with growth inhibitory functions, such as miRNAs, have been closely linked to the presence of cell CpG island promoter hypermethylation.The goal of the aforementioned Research Topic is to bring together the key experimental and theoretical research, linking state-of-the-art knowledge about the epigenetic mechanisms involved in animal virus-cell interactions. |
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2. |
Record Nr. |
UNINA9910148777703321 |
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Autore |
Tutu Archbishop Desmond |
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Titolo |
Book of Forgiving, The : The Fourfold Path for Healing Ourselves and Our World |
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Disciplina |
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Lingua di pubblicazione |
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Formato |
Musica |
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Livello bibliografico |
Monografia |
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Sommario/riassunto |
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The Book of Forgiving, written together by the Nobel Peace Laureate Archbishop Desmond Tutu, and his daughter Revd Mpho Tutu, offers a deeply personal testament and guide to the process of forgiveness.All |
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of us have at times needed both to forgive and be forgiven - whether small, everyday harms or real traumas. But the path to forgiveness is not easy, and the process unclear. How do we let go of resentment when we have been harmed, at times irreparably? How do we forgive and still pursue justice? How do we heal our hearts? How do we heal the harm we have caused others? And how do we forgive ourselves?Drawing on his memories of reconciliation in post-apartheid South Africa, Archbishop Desmond Tutu offers four concrete steps to forgiving and being forgiven:1) Admitting the wrong and acknowledging the harm2) Telling one's story and witnessing the anguish3) Asking for forgiveness and granting forgiveness4) Renewing or releasing the relationshipEach chapter contains reflections and personal stories, as well as exercises for practising each step of the path. The Book of Forgiving is a touchstone and tool for anyone seeking the freedom of forgiveness: an inspiring guide to healing ourselves and creating a more united world. |
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