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Record Nr. |
UNINA9910134853003321 |
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Titolo |
Metallomics : analytical techniques and speciation methods / / edited by Bernhard Michalke |
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Pubbl/distr/stampa |
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Weinhem, Germany : , : Wiley-VCH, , [2016] |
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©2016 |
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ISBN |
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3-527-69493-5 |
3-527-69491-9 |
3-527-69490-0 |
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Descrizione fisica |
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1 online resource (499 p.) |
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Disciplina |
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Soggetti |
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Metals - Physiological effect |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Nota di contenuto |
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Cover; Title Page; Copyright; Contents; List of Contributors; Preface; Part I Analytical Methods and Strategies in Metallomics; Chapter 1 The Position of Metallomics Within Other Omics Fields; 1.1 Introduction; 1.2 Metallome and Metallomics in Relation to Other ""-Ome"" and ""-Omics"" Fields; 1.2.1 Genomics; 1.2.2 Transcriptomics; 1.2.3 Proteomics; 1.2.4 Metabolomics; 1.2.5 Metallomics; 1.3 Is Metallomics Feasible as a Global Study of the Metallome; 1.4 Approaching the Metallome: Study of Metallome Subgroups; 1.5 Analytical Strategies in Metallomics; 1.5.1 Element Mass Spectrometry (ICP-MS) |
1.5.2 Coupling Techniques1.5.3 Elemental Imaging Techniques; 1.5.4 Bioinformatic Approaches; 1.6 Functional Connections Between DNA, Proteins, Metabolites, and Metals; 1.7 Metallothiolomics as Example for Metallomics Studies of a Metallome Subgroup; 1.8 Concluding Remarks; References; Chapter 2 Coupling Techniques and Orthogonal Combination of Mass Spectrometric Techniques; 2.1 Introduction; 2.2 Analytical Techniques for Metallomics; 2.2.1 Overview about Available Separation Techniques; 2.3 Ionization Principles and Mass Spectrometric Detectors for Speciation |
2.3.1 Element-Specific Detection with ICP-Based Techniques2.3.2 Electrospray Ionization-Mass Spectrometry (ESI-MS); 2.3.3 Matrix-Assisted Laser Desorption/Ionization-Mass Spectrometry Techniques |
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(MALDI-MS); 2.4 Overview about Coupling Techniques; 2.4.1 LC Couplings; 2.4.2 Coupling of CE and ICP-MS; 2.4.3 Laser Ablation (LA); 2.4.4 Gas Chromatography (GC); 2.5 Final Remarks and Outlook; References; Chapter 3 Quality Control in Speciation Analysis Using HPLC with ICP-MS and ESI MS/MS: Focus on Quantitation Strategies Using Isotope Dilution Analysis; 3.1 Introduction |
3.2 Synergetic Use of Elemental and Organic Mass Spectrometry in Compound Quantitation and Quality Assurance of Food Selenium Speciation3.2.1 Quality Assurance in Species Quantitation; 3.2.2 Quality Assurance in Species Identification; 3.3 The Role of Species-Specific Isotope Dilution in Increasing Metrological Traceability for the Quantification of Bioinorganic Species; 3.3.1 IDMS and Speciation Analysis; 3.3.2 Quantitative Se Speciation in Food/Supplements by Species-Specific IDMS: Production of ""Speciated"" Reference Materials |
3.3.3 Species-Specific Double IDMS Quantification of Plasma Selenoproteins: Advantages and Limitations in Comparison with the Species-Unspecific IDMS Approach3.3.4 Application of Species-Specific Double Spike IDMS to Account for Redox Exchange between Cr(III) and Cr(VI) Species: Practical Considerations for Quality Assurance; References; Chapter 4 Novel Methods for Bioimaging Including LA-ICP-MS, NanoSIMS, TEM/X-EDS, and SXRF; 4.1 Introduction; 4.2 Bioimaging by LA-ICP-MS; 4.2.1 Principle; 4.2.2 Elemental Bioimaging by LA-ICP-MS; 4.2.3 Quantitative Bioimaging by LA-ICP-MS |
4.2.4 Proteomic Bioimaging by LA-ICP-MS |
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