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1. |
Record Nr. |
UNINA9910480680703321 |
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Autore |
Kise Jane A. G. |
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Titolo |
Differentiated school leadership : effective collaboration, communication, and change through personality type / / Jane A. G. Kise, Beth Russell ; acquisitions editor Rachel Livsey ; copy editor Paula L. Fleming ; cover designer Lisa Miller |
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Pubbl/distr/stampa |
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Thousand Oaks, California : , : Corwin Press, , 2008 |
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©2008 |
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ISBN |
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1-4522-9322-8 |
1-4522-9678-2 |
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Descrizione fisica |
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1 online resource (233 p.) |
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Disciplina |
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Soggetti |
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Educational leadership |
School supervision |
School management and organization |
Electronic books. |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Description based upon print version of record. |
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Nota di bibliografia |
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Includes bibliographical references and index. |
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Nota di contenuto |
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Cover; Contents; Table of Professional Development Activities; A Note From the Authors; Acknowledgments; About the Authors; Introduction: Leading Through Your Strengths; Chapter 1 - What Type of Leader Are You?; Chapter 2 - Strengths-Based Leadership Priorities: You Can't Do It All; Chapter 3 - Succeeding at School Change; Chapter 4 - Your Leadership Team: Distributing Roles Effectively; Chapter 5 - Communicating So That What You Say Is What They Hear; Chapter 6 - Making Professional Learning Communities Worth the Effort; Chapter 7 - Observing All Types of Teachers |
Chapter 8 - Tools for Schoolwide DisciplineChapter 9 - Working With All Types of Parents; Chapter 10 - Strategies for Coping With the Stress of School Leadership; Resource A: Descriptions of Leadership Styles for the 16 Types; Resource B: Problem-Solving, or Z, Model; Resource C: Making Type a Schoolwide Language; Resource D: Further Reading on Personality Type; References; Index |
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Sommario/riassunto |
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This resource shows how an understanding of personality types and |
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adults' individual leadership styles helps build school teams that can collaborate and distribute leadership responsibilities more effectively. |
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2. |
Record Nr. |
UNINA9910571891303321 |
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Autore |
Evans John <1949 June 2-> |
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Titolo |
X-ray absorption spectroscopy for the chemical and materials sciences / / Professor, John Evans, Chemistry, University of Southampton, UK, Diamond Light Source, UK |
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Pubbl/distr/stampa |
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ISBN |
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1-118-67618-1 |
1-118-67617-3 |
1-118-67616-5 |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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3. |
Record Nr. |
UNINA9910132304003321 |
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Titolo |
Blood-brain barrier in drug discovery : optimizing brain exposure of CNS drugs and minimizing brain side effects for peripheral drugs / / edited by Li Di, Edward H. Kerns |
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Pubbl/distr/stampa |
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Hoboken, New Jersey : , : John Wiley & Sons Inc., , [2015] |
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©2015 |
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ISBN |
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1-118-78852-4 |
1-118-78854-0 |
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Edizione |
[1st ed.] |
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Descrizione fisica |
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1 online resource (607 p.) |
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Disciplina |
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Soggetti |
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Brain - Effect of drugs on |
Blood-brain barrier |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Description based upon print version of record. |
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Nota di bibliografia |
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Includes bibliographical references and index. |
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Nota di contenuto |
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Machine generated contents note: Summary List of Chapters1. Overview/Introduction / Li Di (Pfizer Inc.), Edward H. Kerns (Pharmacokinetics of Brain Exposure)2. Pharmacokinetics of CNS penetration / Andreas Reichel (Bayer)3. Free Drug Hyposthesis for CNS Drug Candidates / Xingrong Liu (Genentech)4. Species Differences and impact of desease state on BBB / Jean-Marie Nicolas (UCB Pharma S.A.)Mechanisms of Drugs Across the Blood-Brain Barrier5. Passive diffusion permeability of the BBB - examples and SAR / Phil Jeffrey (GSK)6. Efflux transport at the BBB - examples and SAR / Jerome Hochman (Merck)7. Uptake transport at the BBB - examples and SAR / Zack Cheng (AstraZeneca)8. Uptake of proteins and antibodies at the BBB / William Pardridge (UCLA)Predicting and Measuring Brain Exposure of Drugs9. In silico tools for assessing brain exposure / Hongming Chen (AstraZeneca)10. In vitro assays for assessing BBB permeability - vascular cells, artificial membranes, brain slice, cell uptake / Winfried Neuhaus (University of Vienna)11. Human-based in vitro endothelial cell models / Eric Shusta (University of Wisconsin)12. In vitro assays for assessing brain binding / Li Di (Pfizer)13. In vivo studies of brain exposure / Edward H. Kerns14. PBPK models for BBB / Elizabeth de Lange (Leiden University)15. PK/PD modeling of CNS drug candidates / |
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Johan Gabrielsson (Swedish University)16. Microdialysis to assess free drug concentration in brain / William Kielbasa (Lilly)17. Imaging technique for CNS drug discovery / Lei Zhang (Pfizer Inc.)Modulating Brain Penetration of Leads During Drug Discovery18. Designing CNS drugs for optimal brain exposure / Zoran Rankovic (Lilly)19. Case studies of CNS drug optimization - medicinal chemistry and CNS biology perspectives / Kevin J. Hodgetts (Harvard NeuroDiscovery Center)20. Designing peripheral drugs for minimal brain exposue / Peter Bungay (Pfizer)21. Case studies of non-CNS drugs to minimize brain penetration - Nonsudative antihistamines / Andrew Crowe (Curtin University)Case Studies in CNS Drug Discovery22. Case study 1 on discovery of a successful CNS drug - Fycompa (AMPA Receptor Antagonist) / Andrew Satlin and Antonio Laurenza (Eisai)23. Case study 2 on discovery of a successful CNS drug - Vortioxetine (Serotonin Modulator and Stimulator) / Benny Bang-Andersen (Lundbeck)Drug Delivery Techniques to CNS24. Brain delivery using nanotechnology / Xinguo Jiang (Fudan University)25. Intranasal delivery to CNS / Lisbeth Illum (University of Nottingham)Future Prospective in Blood Brain Barrier Advancement26. Conclusion Remarks / Joan Abbott (King's College). |
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Sommario/riassunto |
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"Focused on central nervous system (CNS) drug discovery efforts, this book educates drug researchers about the blood-brain barrier (BBB) so they can affect important improvements in one of the most significant - and most challenging - areas of drug discovery. Written by world experts to provide practical solutions to increase brain penetration or minimize CNS side-effects. Reviews state-of-the-art in silico, in vitro, and in vivo tools to assess brain penetration and advanced CNS drug delivery strategies. Covers BBB physiology, medicinal chemistry design principles, free drug hypothesis for the BBB, and transport mechanisms including passive diffusion, uptake/efflux transporters, and receptor-mediated processes. Highlights the advances in modelling BBB pharmacokinetics and dynamics relationships (PK/PD) and physiologically-based pharmacokinetics (PBPK). Discusses case studies of successful CNS and non-CNS drugs, lessons learned and paths to the market"--Provided by publisher. |
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