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Record Nr. |
UNINA9910132261703321 |
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Titolo |
Antitargets and drug safety / / edited by Lásló Urbán, Vinod F. Patel, and Roy J. Vaz |
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Pubbl/distr/stampa |
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Weinheim, Germany : , : Wiley-VCH, , [2015] |
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©2015 |
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ISBN |
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3-527-67364-4 |
3-527-67366-0 |
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Descrizione fisica |
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1 online resource (1266 p.) |
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Collana |
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Methods and principles in medicinal chemistry ; ; volume 66 |
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Disciplina |
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Soggetti |
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Drugs - Side effects |
Drugs - Side effects - Prevention |
Drug interactions |
Drug development |
Drugs - Structure-activity relationships |
Drug-Related Side Effects and Adverse Reactions |
Protein Kinase Inhibitors - adverse effects |
Pharmacovigilance |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Description based upon print version of record. |
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Nota di bibliografia |
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Includes bibliographical references and index. |
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Nota di contenuto |
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section 1. General concept for target-based safety assessment -- section 2. Hepatic side effects -- section 3. Cardiovascular side effects -- section 4. Kinase antitargets -- section 5. Examples of clinical translation. |
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Sommario/riassunto |
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With its focus on emerging concerns of kinase and GPCR-mediated antitarget effects, this vital reference for drug developers addresses one of the hot topics in drug safety now and in future. Divided into three major parts, the first section deals with novel technologies and includes the utility of adverse event reports to drug discovery, the translational aspects of preclinical safety findings, broader computational prediction of drug side-effects, and a description of the serotonergic system. The main part of the book looks at some of the most common antitarget-mediated side effects, focusing |
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