| |
|
|
|
|
|
|
|
|
1. |
Record Nr. |
UNINA9910639987703321 |
|
|
Autore |
Udrescu Lucreția |
|
|
Titolo |
In Silico Strategies for Prospective Drug Repositionings |
|
|
|
|
|
Pubbl/distr/stampa |
|
|
Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 |
|
|
|
|
|
|
|
ISBN |
|
|
|
|
|
|
Descrizione fisica |
|
1 electronic resource (288 p.) |
|
|
|
|
|
|
Soggetti |
|
Medicine |
Pharmaceutical industries |
|
|
|
|
|
|
|
|
Lingua di pubblicazione |
|
|
|
|
|
|
Formato |
Materiale a stampa |
|
|
|
|
|
Livello bibliografico |
Monografia |
|
|
|
|
|
Sommario/riassunto |
|
The discovery of new drugs is one of pharmaceutical research's most exciting and challenging tasks. Unfortunately, the conventional drug discovery procedure is chronophagous and seldom successful; furthermore, new drugs are needed to address our clinical challenges (e.g., new antibiotics, new anticancer drugs, new antivirals).Within this framework, drug repositioning—finding new pharmacodynamic properties for already approved drugs—becomes a worthy drug discovery strategy.Recent drug discovery techniques combine traditional tools with in silico strategies to identify previously unaccounted properties for drugs already in use. Indeed, big data exploration techniques capitalize on the ever-growing knowledge of drugs' structural and physicochemical properties, drug–target and drug–drug interactions, advances in human biochemistry, and the latest molecular and cellular biology discoveries.Following this new and exciting trend, this book is a collection of papers introducing innovative computational methods to identify potential candidates for drug repositioning. Thus, the papers in the Special Issue In Silico Strategies for Prospective Drug Repositionings introduce a wide array of in silico strategies such as complex network analysis, big data, machine learning, molecular docking, molecular dynamics simulation, and QSAR; these strategies target diverse diseases and medical conditions: COVID-19 and post-COVID-19 pulmonary fibrosis, non-small lung |
|
|
|
|
|
|
|
|
|
|
|
|
|
cancer, multiple sclerosis, toxoplasmosis, psychiatric disorders, or skin conditions. |
|
|
|
|
|
|
2. |
Record Nr. |
UNINA9910131517103321 |
|
|
Autore |
Audoin-Rouzeau Frédérique <1957-> |
|
|
Titolo |
Les chemins de la peste : le rat, la puce et l'homme |
|
|
|
|
|
Pubbl/distr/stampa |
|
|
Presses universitaires de Rennes, 2003 |
|
[Place of publication not identified], : Presses universitaires de Rennes, 2003 |
|
|
|
|
|
|
|
|
|
ISBN |
|
|
|
|
|
|
|
|
Descrizione fisica |
|
1 online resource (372 p.) |
|
|
|
|
|
|
Soggetti |
|
Yersinia Infections |
History |
Enterobacteriaceae Infections |
Humanities |
Gram-Negative Bacterial Infections |
Bacterial Infections |
Bacterial Infections and Mycoses |
Disease |
History of Medicine |
Plague |
Medicine |
Health & Biological Sciences |
Infectious Diseases |
|
|
|
|
|
|
|
|
Lingua di pubblicazione |
|
|
|
|
|
|
Formato |
Materiale a stampa |
|
|
|
|
|
Livello bibliografico |
Monografia |
|
|
|
|
|
Note generali |
|
Bibliographic Level Mode of Issuance: Monograph |
|
|
|
|
|
|
Sommario/riassunto |
|
La peste, ce fléau majeur de l'histoire des hommes est pour beaucoup une maladie historique, dépassée, dont l'énigme de la propagation |
|
|
|
|
|
|
|
|
|
|
semble résolue. Il n'en est rien. Dans la lutte séculaire que l'homme mène contre la peste, la connaissance précise des modes de sa dispersion forment un élément-clé. Ainsi l'identification des puces responsables de l'épidémisation constitue-t-elle un enjeu de première importance. |
|
|
|
|
|
| |