Certayne necessarie principles of religion, which may be entituled, A catechisme conteyning all the partes of the Christian and Catholique fayth [[electronic resource] /] / written in Latin by P. Canitius .

• Record Nr.: UNISA996393335903316
• Autore: Canisius Petrus, Saint, <1521-1597.>
• Pubbl/distr/stampa: Duaci [i.e. London?], : Per Ioannem Bogardum [i.e. William Carter?], [1579?]
• Descrizione fisica: [141] p
• Lingua di pubblicazione: Inglese
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Note generali: Translation of and additions to Parvus catechismus Catholicorum--Cf. NUC pre-1956 imprints.; Running title: A catechisme for Catholiques.; Corrections to possible fictitious imprint suggested by STC (2nd ed.) and NUC pre-1956 imprints.; Signatures: [par.]⁸(-par.1) A-H⁸.; Imperfect: signature [par.]8 lacking; stained and tightly bound with slight loss of print.; Reproduction of original in the British Library.
• Sommario/riassunto: eebo-0018

RNA Metabolism in Neurodegenerative Diseases / / edited by Rita Sattler, Christopher J. Donnelly

• Record Nr.: UNINA9910298433003321
• Pubbl/distr/stampa: Cham : , : Springer International Publishing : , : Imprint : Springer, , 2018
• ISBN: 3-319-89689-X
• Edizione: [1st ed. 2018.]
• Descrizione fisica: 1 online resource (321 pages)
• Collana: Advances in Neurobiology, , 2190-5215 ; ; 20
• Disciplina: 616.8047
• Soggetti: Neurosciences
• Lingua di pubblicazione: Inglese
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Nota di contenuto: RNA Metabolism in Neurodegenerative Diseases -- Mechanism of Splicing Regulation of Spinal Muscular Atrophy Genes -- RNA Editing Deficiency in Neurodegeneration -- RNA Nucleocytoplasmic Transport Defects in Neurodegenerative Diseases -- RNA Degradation in Neurodegenerative Disease -- RNP Assembly Defects in Spinal Muscular Atrophy -- Stress Granules and ALS: A Case of Causation or Correlation? -- Deregulation of RNA Metabolism in Microsatellite Expansion Diseases -- Mechanisms Associated with TDP-43 Neurotoxicity in ALS/FTLD -- Senataxin, a Novel Helicase at the Interface of RNA Transcriptome Regulation and Neurobiology: From Normal Function to Pathological Roles in Motor Neuron Disease and Cerebellar Degeneration -- Lost in Translation – Evidence for Protein Synthesis Deficits in ALS/FTD and Related Neurodegenerative Diseases.
• Sommario/riassunto: It has become evident over the last years that abnormalities in RNA processing play a fundamental part in the pathogenesis of neurodegenerative diseases. Cellular viability depends on proper regulation of RNA metabolism and subsequent protein synthesis, which requires the interplay of many processes including transcription, pre‐mRNA splicing, mRNA editing as well as mRNA stability, transport and translation. Dysfunction in any of these processes, often caused by mutations in the coding and non‐coding RNAs, can be very destructive to the cellular environment and consequently impair neural viability. The result of this RNA toxicity can lead to a toxic gain of function or a ; loss of function, depending on the nature of the mutation. For example, in repeat expansion disorders, such as the newly discovered hexanucleotide repeat expansion in theC9orf72 gene found in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), a toxic gain of function leads to the formation of RNA foci and the sequestration of RNA binding proteins (RBPs). This in return leads to a loss of function of those RBPs, which is hypothesized to play a significant part in the disease progression of ALS and FTD. Other toxicities arising from repeat expansions are the formation of RNA foci, bi‐directional transcription and production of repeat associated non‐ATG (RAN) translation products. This book will touch upon most of these disease mechanisms triggered by aberrant RNA metabolism and will therefore provide a broad perspective of the role of RNA processing and its dysfunction in a variety of neurodegenerative disorders, including ALS, FTD, Alzheimer’s disease, Huntington’s disease, spinal muscular atrophy, myotonic dystrophy and ataxias. The proposed authors are leading scientists in the field and are expected to not only discuss their own work, but to be inclusive of historic as well as late breaking discoveries. The compiled chapters will therefore provide a unique collection of novel studies and hypotheses aimed to describe the consequences of altered RNA processing events and its newest molecular players and pathways.

Superradiance : Energy Extraction, Black-Hole Bombs and Implications for Astrophysics and Particle Physics / / by Richard Brito, Vitor Cardoso, Paolo Pani

• Record Nr.: UNINA9910131491503321
• Autore: Brito Richard
• Pubbl/distr/stampa: Cham : , : Springer International Publishing : , : Imprint : Springer, , 2015
• ISBN: 3-319-19000-8
• Edizione: [1st ed. 2015.]
• Descrizione fisica: 1 online resource (XIII, 237 p. 63 illus., 52 illus. in color.)
• Collana: Lecture Notes in Physics, , 1616-6361 ; ; 906
• Disciplina: 535
• Soggetti: Gravitation; Cosmology; Elementary particles (Physics); Quantum field theory; Classical and Quantum Gravity; Elementary Particles, Quantum Field Theory
• Lingua di pubblicazione: Inglese
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Note generali: Bibliographic Level Mode of Issuance: Monograph
• Nota di contenuto: Introduction -- Superradiance in flat spacetime -- Superradiance in black hole physics -- Black holes and superradiant instabilities -- Black hole superradiance in astrophysics -- Conclusions and Outlook.
• Sommario/riassunto: This volume gives a unified picture of the multifaceted subject of superradiance, with a focus on recent developments in the field, ranging from fundamental physics to astrophysics. Superradiance is a radiation enhancement process that involves dissipative systems. With a 60 year-old history, superradiance has played a prominent role in optics, quantum mechanics and especially in relativity and astrophysics. In Einstein's General Relativity, black-hole superradiance is permitted by dissipation at the event horizon, which allows energy extraction from the vacuum, even at the classical level. When confined, this amplified radiation can give rise to strong instabilities known as "blackhole bombs'', which have applications in searches for dark matter, in physics beyond the Standard Model and in analog models of gravity. This book discusses and draws together all these fascinating ; aspects of superradiance.