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Record Nr. |
UNINA9910131471703321 |
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Titolo |
The treatment of epilepsy / / edited by Simon Shorvon, Emilio Perucca, Jerome Engel, Jr. ; contributors, Patrick Adjei [and one hundred thirty others] |
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Pubbl/distr/stampa |
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Chichester, England : , : Wiley Blackwell, , 2016 |
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©2016 |
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ISBN |
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1-118-93697-3 |
1-118-93699-X |
1-118-93698-1 |
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Edizione |
[Fourth edition.] |
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Descrizione fisica |
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1 online resource (2765 p.) |
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Disciplina |
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Soggetti |
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Epilepsy - Surgery |
Anticonvulsants - Therapeutic use |
Epilepsy - Chemotherapy |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Description based upon print version of record. |
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Nota di bibliografia |
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Includes bibliographical references and index. |
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Nota di contenuto |
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Title page; Copyright; List of Contributors; Preface to the Fourth Edition; Preface to the First Edition; Historical Introduction The Drug Treatment of Epilepsy from 1857 to 2015; Commentary; Acknowledgement; References; Section I Introduction; 1 Definition (Terminology) and Classification in Epilepsy: A Historical Survey and Current Formulation, with Special Reference to the ILAE; Definition; Classification; The future of classification schemes of epilepsy; Definition; Definition and classification - status epilepticus; Afterthought; Acknowledgement; References |
2 Differential Diagnosis of EpilepsyIntroduction; General approach to the diagnosis of episodic disturbances; Syncope; Non-epileptic seizures; Panic disorder; Migraine; Sleep disorders; Vertigo; Movement disorders; Cerebral ischaemia; Endocrine and metabolic abnormalities; Transient global amnesia; References; 3 Mechanisms of Epileptogenesis; Membrane ion channels; Membrane ion channels as targets for antibodies in acquired autoimmune disorders; Network and system involvement in epileptogenesis; Epileptogenesis as a process; |
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New targets for antiepileptic and antiepileptogenic strategies |
ConclusionsReferences; 4 Antiepileptic Drug Discovery; Characteristics of the ideal model system; The current era of AED discovery; Anticonvulsant Screening Program; Early identification of antiepileptic activity; MES, scPTZ and 6-Hz tests; Differentiation of anticonvulsant activity; Pharmacological profile and potential clinical utility; Pharmacoresistant seizure models; Therapeutic index and toxicity assessment; Aetiologically relevant model systems; Beyond the seizure; Antiepileptogenesis and disease modification (see also Chapter 8); Conclusions; Acknowledgement; References |
5 Antiepileptic Drug DevelopmentIntroduction; Overview on clinical studies and trials for drug development; Opportunities for developing better antiseizure AEDs; Development of epilepsy drugs beyond suppressing seizures; Conclusions; Acknowledgements; References; 6 Mechanisms of Antiepileptic Drug Action; Main targets; Other targets; References; 7 Mechanisms of Drug Resistance and Tolerance; Introduction; The concept of drug resistance in epilepsy; Disease-related mechanisms of drug resistance in epilepsy; Drug-related mechanisms of drug resistance in epilepsy |
Pharmacogenetic mechanisms of drug resistance in epilepsyProof-of-concept of drug resistance hypotheses; Conclusions; References; 8 Epilepsy Biomarkers; Introduction; Need for biomarkers; Mechanisms of epilepsy; Potential biomarkers; Research to identify biomarkers; Acknowledgements; References; Section II Principles of Medical Management; 9 General Principles of Medical Management; Aims of treatment; When should treatment be started?; Initiation of treatment and dose optimization; Assessing clinical response; What next when the initial treatment fails? - monotherapy and combination therapy |
How long should treatment be continued? |
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2. |
Record Nr. |
UNINA9910484151803321 |
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Autore |
Martinelli Dario |
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Titolo |
What You See Is What You Hear : Creativity and Communication in Audiovisual Texts / / by Dario Martinelli |
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Pubbl/distr/stampa |
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Cham : , : Springer International Publishing : , : Imprint : Springer, , 2020 |
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ISBN |
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Edizione |
[1st ed. 2020.] |
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Descrizione fisica |
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1 online resource (293 pages) |
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Disciplina |
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Soggetti |
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Arts |
Communication |
Sociology |
Cultural studies |
Music |
Performing arts |
Communication Studies |
Media Research |
Cultural Studies |
Performing Arts |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Nota di contenuto |
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Defining And Classifying Of Audiovisual Texts -- Understanding Audiovisual Communication -- Axes: Time And Space -- Means: Sound, Image And Language -- Properties: Taxonomy, Culture, Thematicity, Performance, Technology. |
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Sommario/riassunto |
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What You See Is What You Hear develops a unique model of analysis that helps students and advanced scholars alike to look at audiovisual texts from a fresh perspective. Adopting an engaging writing style, the author draws an accessible picture of the field, offering several analytical tools, historical background, and numerous case studies. Divided into five main sections, the monograph covers problems of definitions, history, and most of all analysis. The first part raises the main problems related to audiovisuality, including taxonomical and |
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historical questions. The second part provides the bases for the understanding of audiovisual creative communication as a whole, introducing a novel theoretical model for its analysis. The next three part focus elaborate on the model in all its constituents and with plenty of case studies taken from the field of cinema, TV, music videos, advertising and other forms of audiovisuality. Methodologically, the book is informed by different paradigms of film and media studies, multimodality studies, structuralism, narratology, “auteur theory” in the broad sense, communication studies, semiotics, and the so-called “Numanities.” What You See Is What You Hear enables readers to better understand how to analyze the structure and content of diverse audiovisual texts, to discuss their different idioms, and to approach them with curiosity and critical spirit. |
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