Atherosclerosis : risks, mechanisms and therapies / / edited by Hong Wang and Cam Patterson ; co-editors, Domenico Praticò [and others]

• Record Nr.: UNINA9910131152203321
• Pubbl/distr/stampa: Hoboken, New Jersey : , : John Wiley & Sons, , 2015; ©2015
• ISBN: 1-118-82853-4; 1-118-82855-0
• Descrizione fisica: 1 online resource (631 p.)
• Disciplina: 616.136
• Soggetti: Atherosclerosis; Atherosclerosis - Pathophysiology; Atherosclerosis - Prevention
• Lingua di pubblicazione: Inglese
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Note generali: Description based upon print version of record.
• Nota di bibliografia: Includes bibliographical references and index.
• Nota di contenuto: Title Page; Copyright Page; Contents; Contributors; Foreword; Preface; Section I Risk Factors: Old and New; Chapter 1 Lipoproteins; Brief History of Cholesterol and Atherosclerosis; Lipoproteins; LDL and Atherosclerosis; Triglyceride-Rich Lipoproteins and Atherosclerosis; HDL and Atherosclerosis; Summary; References; Chapter 2 Role of Dysglycemia in Atherosclerosis; Introduction; Molecular Mechanisms by Which Dysglycemia Accelerates Atherosclerosis; Dysglycemia and Endothelial Cells; Dysglycemia and Vascular Smooth Muscle Cells; Dysglycemia and Macrophages; Conclusion; Acknowledgments; References Chapter 3 Glycation, Inflammation and RAGE: Mechanisms Contributing to the Accelerated Atherosclerosis of Diabetes; Introduction; Animal Models of Diabetic Atherosclerosis; Glycation of Proteins and Lipids: Potential Impact on Atherosclerosis; Non-RAGE Glycation Receptors and Implications for Atherosclerosis; RAGE and Implications for Diabetic Atherosclerosis; Glycation and Rage-Studies in Human Subjects; Conclusions; References; Chapter 4 Inflammation; Introduction; Monocyte Recruitment to the Vessel Wall; Chemokines; Cytokines; Shear Stress and Inflammation; Mechanisms of Flow-Induced Inflammation Conclusions; References; ; Chapter 5 Homocysteine: A Controversial Cardiovascular Risk Factor; Introduction; Epidemiological Studies: Establishment of Homocysteine as a Risk Factor; Animal Models of Hyperhomocysteinemia; Clinical Intervention Trials; Summary and Perspectives; References; Chapter 6 Hypertension as a Risk Factor for Atherosclerosis; Introduction; Evidence Linking Atherosclerosis and Hypertension; Molecular and Cellular Mechanisms Linking Hypertension and Atherosclerosis; Implications for Treatment and Future Directions; References; Chapter 7 The Genetics of Atherosclerosis: From Polymorphisms to Populations Introduction; Lessons from Mendelian Diseases-Familial Hypercholesterolemia; Role for Genetic Diagnosis and Screening; Genetically Isolated Population Studies: Implications for Atherosclerosis in the General Population; GWAS to Identify Atherosclerosis Risk Genes in the General Population; Identification of a Risk Allele Located at 9P21 by GWAS; Technologic Advances and the Future; Conclusion; Acknowledgments; References; Chapter 8 Life Style; Introduction; Lifestyle Factors and Cardiovascular Disease; Lifestyle Factors and Cardiovascular Disease in the Young Physical Activity; Diet and Nutrition; Environmental Effects; Ambient Air Pollution; Other Environmental Factors; Summary; References; Section II Cellular Mechanisms; Chapter 9 Endothelial Cells; Introduction; Endothelial Nitric Oxide; Flow and Arterial Shear Stress; Peroxisome Proliferator-Activated Receptor Nuclear Receptor Family; Endothelial Progenitor Cells; Future Directions; References; Chapter 10 Vascular Smooth Muscle Cells; Introduction; SMCS in Atheroma Progression; Extrinsic Control of SMC Biology; Intrinsic Control of SMC Biology
• Sommario/riassunto: Comprehensive and in-depth in its coverage, Atherosclerosis: Cellular, Molecular & Biochemical Mechanism and Novel Therapy reviews the recent progress in atherosclerosis research and offers cutting edge perspectives from experts in the field. Written by an international team of authors including leading physician-scientists, research experts and physicians, chapters are divided into four major sections, covering risk factors, cellular and molecular mechanisms, biochemical mechanisms and novel and future therapeutics. Atherosclerosis: Cellular, Molecular & Biochemical Mechanism and Novel

Blood, Sweat & Tears : Becoming a Better Surgeon

• Record Nr.: UNINA9910955811303321
• Autore: Stahel Philip F
• Pubbl/distr/stampa: Shrewsbury : , : TFM Publishing Ltd, , 2016; ©2016
• ISBN: 9781910079300; 1910079308; 9781910079287; 1910079286
• Edizione: [1st ed.]
• Descrizione fisica: 1 online resource (296 pages)
• Disciplina: 617/.0232
• Soggetti: Surgery - Vocational guidance; Surgeons; General Surgery; Clinical Competence; Patient Safety; Personal Narrative
• Lingua di pubblicazione: Inglese
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Nota di contenuto: Blood, Sweat &amp -- Tears: Becoming a Better Surgeon -- Title Page -- Copyright -- Contents -- The author: Philip F. Stahel, MD, FACS -- About this book -- Foreword: By Marty Makary, MD, MPH -- Dedication -- PART 1: A surgeon's journey to empathetic patient care -- Chapter 1: Blood &amp -- sweat: hardship of a surgical intern -- Chapter 2: Tears a 20-year process -- Chapter 3: Learning empathy from monsters and muppets -- PART 2: The better surgeon -- Chapter 4: We learn how to cut, but not how to listen -- Chapter 5: Let's stop making stuff up! -- Chapter 6: A crash course on probability -- Chapter 7: Minimizing risk -- Chapter 8: How to deal with uncertainty -- Chapter 9: You can't fix what you don't know! -- Chapter 10: Individual accountability -- PART 3: The safe patient -- Chapter 11: The "eat-what-you-kill" phenomenon: how to avoid avoidable care -- Chapter 12: Nothing about me, without me! -- Chapter 13: Patient ; advocacy: it's a team approach -- Chapter 14: Questions a patient should ask their surgeon prior to surgery -- PART 4: The unsafe system -- Chapter 15: From 'blame &amp -- shame' to system failure -- Chapter 16: Why our current patient safety protocols are unsafe -- Chapter 17: "See one, do one…" - no time to "teach one -- PART 5: The spiritual surgeon -- Chapter 18: Your time is as valuable as my time -- Chapter 19: How to avoid burnout -- Chapter 20: What we permit, we promote -- Epilogue: By Wade Smith, MD -- Afterword: By Ted J. Clarke, MD -- Acknowledgments -- Abbreviations -- Glossary -- Image copyright -- Index -- Back Cover.
• Sommario/riassunto: All surgeons want to be better surgeons... They work hard to be respected by their peers, appreciated by their patients, and valued by their communities. Most of the estimated 200 million surgeries performed worldwide every year go as anticipated, with positive patient outcomes. However, the number of surgical complications and preventable medical errors still remains unacceptably high. Why are experienced surgeons still creating so many adverse events? More importantly, what can surgeons do to better address the situation? Blood, Sweat and Tears - Becoming a Better Surgeon seeks to answer these questions. The book provides pragmatic examples on how good surgeons can grow from being technically brilliant to becoming empathetic and capable of providing safe, compassionate, and more effective patient care. Blood, Sweat and Tears - Becoming a Better Surgeon follows trauma surgeon Philip Stahel's 20-year journey from his 'rookie years' in internship and residency, to his development as a global patient safety advocate, renowned academician and teacher, and compassionate surgeon. The book touches on why our current patient safety protocols and checklists fail to keep patients safe and how a physician-driven initiative with credible leadership is needed to build a sustainable 'culture of patient safety.' Written for a wide audience and based on the paradigm that "good judgment comes from experience which comes from poor judgment", Blood, Sweat and Tears - Becoming a Better Surgeon provides in-depth coverage of all the critical and timely components of safe surgical care, relates practical tips for improving the quality of partnerships between surgeons and patients, and offers a practical guide on how to reduce the learning curve to becoming a better surgeon. Reviews1) I applaud Dr. Stahel for presenting a rich compilation of his honest and remarkable first-hand experiences and the collective work of doctors and health care leaders to reduce the endemic variation in medical quality that contributes to the #3 cause of death in the U.S. today - medical care itself. Marty Makary MD, Author of The New York Times bestseller, Unaccountable 2) "Blood, Sweat & Tears" is a great book, one of a kind, and destined to be a medical classic. What makes the book exceptional is the narrative about a difficult human endeavor, often done imperfectly, by humans who have been told they should be 'perfect'. This quintessential paradox is why this book is a practical story about life and will likely be of interest and enjoyment to many outside the realm of medicine. Wade Smith MD, Co-founding Editor, Patient Safety in Surgery3) Blood, Sweat & Tears: How to Become a Better Surgeon is a remarkable book that emphasizes empathy and communication, provocatively authored by a surgeon. However, as the reader will soon discover, Philip Stahel is not your ordinary surgeon. I strongly recommend every health care provider read this book. I further recommend this book be mandatory reading annually for every medical student, intern, resident and fellow-in-training, most especially chapters 3 and 4, which epitomize William Osler's advice, "Listen to the patient - he is telling you the diagnosis". In these 20 chapters, the ; many other insightful quotes alone are worth the purchase price.Jerome M.Buckley, MDRetired CEO/Chairman, COPIC CompaniesAssociate Clinical Professor, University of Colorado School of Medicine 4) The life of a surgeon is difficult. Life and limb threatening problems do not necessarily occur at convenient times. Surgery is not for the weak as it requires physical strength, emotional stamina, and unquenchable intellectual curiosity. Underneath these prerequisites lies the most important of all surgical requirements: the patient. With his emphasis on patient care found through empathy, shared decision making, and attention to detail, Dr. Stahel is telling the surgeon of today and tomorrow about the way to quality improvement and self-fulfillment.The emphasis on empathy is a crucial but neglected part of quality improvement. Why do our patients so frequently not adhere to our instructions? Putting yourself in the patient's position creates an essential surgeon-patient bond that underlies an optimal outcome. Dr. Stahel did not write the golden rule of "love thy neighbor as thyself", but it is clear that he sees this as an essential part of the surgeon-patient partnership. Both surgeon and patient will feel this effect, and it will pay dividends for both parties in the near and distant future.It is an important but disturbing reflection that many medical students lose their empathetic qualities during their clerkship years. There are many reasons that underlie this loss including our role models, the frantic pace of clinical activities, and the lack of clear direction as to the medical student role. Importantly, Dr. Stahel gives us a path to finding our empathy by rediscovering our humanism. Relating to the janitor, the nurse, and other members of the care team as people is an important first step in understanding the common ground that we share with our patients. Letting each member of the surgical team call the professor by his first name clearly tells the staff that all are important and essential. Giving his phone number to his patients shows the trust that Dr. Stahel shares with those who trust him.As I reflect upon my own 35-year career in surgery, I remember the eagerness with which I first approached operating room days. "A chance to cut is a chance to cure" and "the only way to heal is with cold steel" were chants that my fellow residents and I would often repeat. The operating room was its own sanctuary away from many realities of patient care. With time, I have learned to appreciate other parts of patient care. In the clinic, I have a chance to know the patient as a person, and I have an opportunity to educate the patient as I would want to be educated. My path to becoming a better surgeon is far from over but my time to accomplish this is short. I truly wish that I had read such a book many decades ago as I began my life in surgery, but back then no such work was available. With Blood, Sweat, & Tears, Dr. Stahel has directed me to some needed tools that might help me reach this laudatory goal of ongoing quality improvement. I am most appreciative for his reflections and observations, and I remain hopeful that perhaps someday I might become a better surgeon.Ted Clarke, MDOrthopaedic Surgeon and CEO and Chairman of COPIC, Denver, Colorado 5) As a veteran Registered Nurse I feel that this book is a must read for anyone in health care! Dr. Philip Stahel has a very down to Earth writing style and compassionate approach to patient care. Reading this book has reinvigorated my love of nursing and passion for patient care. Kerry Olson, RN6) Blood, Sweat & Tears is a unique book - clearly one of a kind, and surprisingly not just of interest to those who work in healthcare. The book has a captivating narrative flow and the medical aspects are very easy to understand for non-clinical/laypersons as well. I will be sending my "baby boomer" parents a copy as it becoming increasingly important for the community to understand the complexity ; and challenges of our current healthcare system. My take-home point from this book is that we can and we should be involved in our healthcare choices and ask important and pertinent questions. If you're like me, and you're interested in patient safety and eventually receiving high quality medical care if you ever become a patient, if you have a sense of humor, and you would like a different perspective on healthcare, this is the book for you! Nicole Morgan, MHA