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UNINA990000163340403321 |
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Autore |
Cicognara, Leopoldo <1767-1834> |
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Titolo |
2. : 141 p., 131 tav. : ill. |
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Pubbl/distr/stampa |
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Venezia : Co' tipi di G. Antonelli, 1840- |
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Descrizione fisica |
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Lingua di pubblicazione |
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Materiale a stampa |
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Livello bibliografico |
Monografia |
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2. |
Record Nr. |
UNINA9910298586003321 |
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Autore |
Chandran Anandhakumar |
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Titolo |
Advancing Development of Synthetic Gene Regulators : With the Power of High-Throughput Sequencing in Chemical Biology / / by Anandhakumar Chandran |
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Pubbl/distr/stampa |
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Singapore : , : Springer Singapore : , : Imprint : Springer, , 2018 |
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ISBN |
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Edizione |
[1st ed. 2018.] |
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Descrizione fisica |
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1 online resource (XV, 114 p. 49 illus., 44 illus. in color.) |
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Collana |
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Springer Theses, Recognizing Outstanding Ph.D. Research, , 2190-5053 |
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Disciplina |
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Soggetti |
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Biotechnology |
Gene therapy |
Bioorganic chemistry |
Gene Therapy |
Bioorganic Chemistry |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Nota di bibliografia |
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Includes bibliographical references. |
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Nota di contenuto |
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Overview of Next-Generation Sequencing Technologies and its application in Chemical Biology -- Next Generation Sequencing Studies Guide the Design of Pyrrole-Imidazole Polyamides with Improved Binding Specificity by the Addition of β-alanine -- Genome-Wide Assessment of the Binding Effects of Artificial Transcriptional Activators by Utilizing the Power of High-Throughput Sequencing -- Deciphering the genomic targets of alkylating polyamide conjugates using high-throughput sequencing. |
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Sommario/riassunto |
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This book focuses on an “outside the box” notion by utilizing the powerful applications of next-generation sequencing (NGS) technologies in the interface of chemistry and biology. In personalized medicine, developing small molecules targeting a specific genomic sequence is an attractive goal. N-methylpyrrole (P)–N-methylimidazole (I) polyamides (PIPs) are a class of small molecule that can bind to the DNA minor groove. First, a cost-effective NGS (ion torrent platform)-based Bind-n-Seq was developed to identify the binding specificity of PIP conjugates in a randomized DNA library. Their biological influences rely primarily on selective DNA binding affinity, so it is important to analyze their genome-wide binding preferences. However, it is demanding to enrich specifically the small-molecule-bound DNA without chemical cross-linking or covalent binding in chromatinized genomes. Herein is described a method that was developed using high-throughput sequencing to map the differential binding sites and relative enriched regions of non-cross-linked SAHA-PIPs throughout the complex human genome. SAHA-PIPs binding motifs were identified and the genome-level mapping of SAHA-PIPs-enriched regions provided evidence for the differential activation of the gene network. A method using high-throughput sequencing to map the binding sites and relative enriched regions of alkylating PIP throughout the human genome was also developed. The genome-level mapping of alkylating the PIP-enriched region and the binding sites on the human genome identifies significant genomic targets of breast cancer. It is anticipated that this pioneering low-cost, high through-put investigation at the sequence-specific level will be helpful in understanding the binding specificity of various DNA-binding small molecules, which in turn will be beneficial for the development of small-molecule-based drugs targeting a genome-level sequence. . |
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3. |
Record Nr. |
UNINA9910139602603321 |
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Autore |
Shim Jae K |
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Titolo |
Budgeting basics and beyond / / Jae K. Shim, Joel G. Siegel, Allison I. Shim |
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Pubbl/distr/stampa |
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Hoboken, N.J., : Wiley, 2012 |
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ISBN |
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1-283-28118-X |
9786613281180 |
1-118-38702-3 |
1-118-12796-X |
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Edizione |
[4th ed.] |
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Descrizione fisica |
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1 online resource (560 p.) |
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Collana |
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Wiley Corporate F&A series |
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Altri autori (Persone) |
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SiegelJoel G |
ShimAllison I. <1984-> |
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Disciplina |
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Soggetti |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Nota di contenuto |
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Machine generated contents note: About the Authors.Preface.Chapter 1: The What and Why of Budgeting: An Introduction.Chapter 2: Strategic Planning and Budgeting: Process, Preparation and Control.Chapter 3: Administering the Budget: Reports, Analyses, and Evaluations.Chapter 4: Break-even and Contribution Margin Analysis: Profit, Cost, and Volume Changes.Chapter 5: Profit Planning: Targeting and Reaching Achievable Goals.Chapter 6: Master Budget: Genesis of Financial Forecasting and Profit Planning.Chapter 7: Cost Behavior: Emphasis on Flexible Budgets.Chapter 8: Evaluating Performance: The Use of Variance Analysis.Chapter 9: Manufacturing Costs: Sales Forecasts and Realistic Budgets.Chapter 10: Marketing: Budgeting for Sales, Advertising, and Distribution.Chapter 11: Research and Development: Budgets for a Long-term Plan.Chapter 12: General and Administrative Costs: Budgets for Maximum Productivity.Chapter 13: Capital Expenditures: Assets to Be Bought, Sold, and Discarded.Chapter 14: Forecasting and Planning: Reducing Risk in Decision Making.Chapter 15: Moving Averages and Smoothing Techniques: Quantitative Forecasting.Chapter 16: Regression Analysis: Popular Sales Forecast System.Chapter 17: Cash Budgeting and Forecasting Cash Flow: Two |
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Pragmatic Methods.Chapter 18: Financial Modeling: Tools for Budgeting and Profit Planning.Chapter 19: Using Software Packages and E-Budgeting: Computer-based Models, Spreadsheets, and Web-based System.Chapter 20: Capital Budgeting: Selecting the Optimum Long-term Investment and Real Options.Chapter 21: Budgeting for Cost Management: Activity-based Budgeting and Life-cycle Budgeting.Chapter 22: Zero-base Budgeting: Priority Budgeting for Best Resource Allocation.Chapter 23: Managers' Performance and Balanced Scorecard: Evaluation on the Division Level.Chapter 24: Budgeting for Service Organizations: Special Features.Chapter 25: Budgeting for Nonprofit Organizations: Diverse Types.Chapter 26: Using Management Games for Executive Training.Appendix I: Present and Future Value Tables.Appendix II: Statistical Table.Glossary of Budgeting and Planning Terms.Index. |
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Sommario/riassunto |
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"Budgeting Basics and Beyond, 4th Edition is a practical, easy-to-use problem-solver and up-to-date reference tool for today's financial and nonfinancial managers in public practice and private industry. It is packed with case studies, illustrations, exhibits, forms, checklists, graphs, samples, and worked-out solutions to a wide variety of budgeting, planning, and control problems. It is a truly valuable resource guaranteed to make the budgeting process effective and hassle-free for all managers who use it. The new edition includes new cost cutting strategies, software packages updates, cloud computing nd, new use of Excel for exponential smoothing, Minitab and SPSS, and updates on cash flow software. The book also includes financial planning and new types of financial modeling, variance analysis, Web-based budgeting, active budgeting illuminating "what-if" analyses throughout, spreadsheet applications, break-even analysis, project analysis, and capital budgeting"-- |
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4. |
Record Nr. |
UNINA9910138912403321 |
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Titolo |
ECOWS '09 : proceedings of the 7th IEEE European Conference on Web Services : Eindhoven, Netherlands, 9-11 November 2009 |
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Pubbl/distr/stampa |
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[Place of publication not identified], : IEEE Computer Society, 2009 |
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ISBN |
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Disciplina |
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Soggetti |
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Web services |
World Wide Web |
Web databases |
Telecommunications |
Electrical & Computer Engineering |
Engineering & Applied Sciences |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Bibliographic Level Mode of Issuance: Monograph |
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